ZFIN Image: Yang et al., 2018, Fig. 5

Image

Figure Caption

Fig. 5

Effects of manipulation of Htr2b on hepatocarcinogenesis and liver fibrosis. 3-dpf wildtype or kras+ larvae were co-treated with dox and SB204741 or BW723C86 for 4 days. More than 20 fish were analyzed in each group. (A,E) IF staining of PCNA on liver sections (A) and quantification of PCNA positive cells (E). (B,F) IF staining of Caspase-3 on liver sections (B) and quantification of apoptotic cells (F). (C,G) IF staining of collagen I on liver sections (C) and quantification of percentage of collagen I positive area (G). (D,H) IF staining of Laminin on liver sections (D) and quantification of percentage of Laminin positive area (H). Livers are marked by dash lines. Arrows indicate examples of co-staining and Int indicates intestine. In all experiments, n = 20 for each group. *P < 0.05, compare to the the group in red. Error bars represented biological replicates. Scale bar: 20 μm.

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Sci. Rep.