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Fig. 5
Notch activity as a potential readout of nuclear position. (A) nort:d2GFP expression reports Notch activity in the neural tube. Arrowhead indicates GFP-negative basally localized neurons. Scale bar: 10?µm. (B) Notch activity (green) is significantly inhibited in progenitors that are adjacent (and basal) to an arrested mitotic cell (magenta) (P<0.01, n=15 for control, n=12 for dnPLK1). (C) Inhibition of Notch signaling (via microinjection of hsp:dnMAML1-P2A-h2bCherry2) promotes differentiation compared with a control injection (hsp:h2bCherry2) (P<0.001 for n=11). Scale bar: 10?µm.
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