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Fig. S5
Effects of cyclopamine and BMS-833923 on Hh signaling during scale regeneration. Fish were treated with cyclopamine or BMS-833923 over a period of 1–4 days after scale removal, and the scales were analyzed on Day 4. Three consecutive scales were removed. Both treatments suppressed the expression of ptch1, the transcriptional target of Hh signaling. Lower panels indicate the corresponding regions visualized by calcium or osteoblast markers before staining with the ptch1 anti-sense RNA probe. Scale bars, 500 µm.
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Reprinted from Developmental Biology, 437(2), Iwasaki, M., Kuroda, J., Kawakami, K., Wada, H., Epidermal regulation of bone morphogenesis through the development and regeneration of osteoblasts in the zebrafish scale, 105-119, Copyright (2018) with permission from Elsevier. Full text @ Dev. Biol.