ZFIN Image: Teitz et al., 2018, Fig. 2

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Fig. 2

Kenpaullone protects against cisplatin-induced HC loss in zebrafish lateral lines in vivo. (A–D) Neuromasts (white dots; green arrows) in the zebrafish head were visualized under identical microscopic conditions by staining with 0.005% DASPEI vital dye after treatment for 20 h with medium alone (A), 5 µM cisplatin (B), 5 µM cisplatin and 50 µM benzamil (C), or 5 µM cisplatin and 50 µM kenpaullone. (E) The DASPEI intensity score (mean ± SEM) with various concentrations (micromolar) of kenpaullone (Ken), benzamil, paroxetine, and cisplatin (CIS). Benzamil and paroxetine protect against cisplatin-induced HC loss in zebrafish (Vlasits et al., 2012). The number of zebrafish tested for each condition ranged from three to 13. ** P, < 0.01 and *** P, < 0.001 by one-way ANOVA followed by a Bonferroni comparison.

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Acknowledgments

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