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Fig. S6
Human variant in BMPR1A reduces protein function.
(A) One cell-stage zebrafish embryos were injected with caBMPR1A or R471H-caBMPR1A mRNA, and assessed at 24 hpf for morphological abnormalities by categorization according to the pictures shown. (B) Graph showing percentage of embryos injected with caBMPR1A (n = 22 embryos) or R471H-caBMPR1A (n = 23 embryos) that fit into each category of morphological abnormality. (C) qPCR showing equal amounts of injected RNA for each condition. Statistics is two-tailed t test.
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