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Fig. 3
Loss of paraxial mesodermal myod expression in adamts5 morphant embryos. (A) Expression of adaxial and paraxial myod in 12 hpf embryos injected with control MO (a, arrowheads), with adamts5 morphant embryos showing substantial loss of paraxial expression (b, open arrowheads), as well as mild loss of paraxial myod expression (b, open arrowheads). Rescue of paraxial myod expression in adamts5 morphants co-injected with mRNA encoding wild-type (c, arrows) or catalytically-inactive E411A (d, arrows) ADAMTS5. Control embryos injected with ADAMTS5 mRNA encoding wild-type ADAMTS5 show unaffected myod expression in paraxial mesoderm (e, arrows). Scale bar = 100 ?m; (B) Quantitation of embryos showing present or absent myod patterning represented in (A).
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Full text @ Int. J. Mol. Sci.