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Fig. 2
Loss of Nodal competence at 75% epiboly is caused by changes in the extracellular part of the pathway. (A) Experimental setup. I and II, Activin A receptor type I and II intracellular domains; LOV, light-oxygen-voltage domain. (B) Photoactivation of OptoAcvRs results in ectopic ntl expression at all stages examined. Ectopic ntl induction was not observed in control embryos that were kept in the dark. The number of embryos with the indicated expression pattern among the total number examined in two biological replicates is shown. All side views are shown with dorsal towards the right. Scale bar: 250 µm.
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