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Fig. S4

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ZDB-IMAGE-180611-58
Publication
Freudenblum et al., 2018 - In vivo imaging of emerging endocrine cells reveals a requirement for PI3K-regulated motility in pancreatic islet morphogenesis.
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Figures for Freudenblum et al., 2018
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Figure Caption

Fig. S4

Dynamics of cell coalescence. Related to Figure 3.

Z-projections from time-lapse image series of pancreatic endocrine cells in pax6b:dsRed;mnx1:memGFP transgenics following Notch inhibitor treatment at 4 dpf. Sample was imaged at 7 dpf, with images acquired every 9 minutes. (A) The indicated cell (arrow) forms a connection to a nearby cluster which strengthens over time (bottom frame, arrowhead). (B) Further time points of the sample shown in (A), projections of a subset of zslices to highlight cell shape changes that accompany coalescence of a single cell with a cluster. (B') dsRed channel shown alone for clarity. Scale bars = 10μm.

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