IMAGE

Fig. S5

ID: ZDB-IMAGE-180420-38
Publication: Dogra et al., 2017 - Opposite effects of Activin type 2 receptor ligands on cardiomyocyte proliferation during development and repair
All Figures: Figures for Dogra et al., 2017

Image

Figure Caption

Fig. S5

inhbaa GOF promotes CM proliferation during ErbB2 signaling inhibition. (a) Experimental setup of PD168393 treatment, EdU exposure, followed by fixation. (b, c) Tg(myl7:nlsDsRedExpress) hearts of PD168393-treated wild-type sibling and inhbaa OE larvae at 120 hpf; α-DsRed (red), EdU (green). White arrowheads point to proliferating CMs (EdU+/DsRed+). (d) Quantification of CM proliferation in PD168393-treated wild-type sibling (n=6) and inhbaa OE (n=6) ventricles at 120 hpf. All cell counts were performed on non-overlapping confocal planes (thickness, 1μm) (data are mean ± s.e.m., ***P ≤ 0.001 - Student’s t-test, two-tailed). Scale bars, 20 μm. vent., ventricle; atr., atrium.

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Nat. Commun.