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Fig. 2
Immunohistochemistry staining using antibodies against (A) megalin and (B) cublin. Biopsies from patients with (a) control, (b) minimal change nephropathy (MCNS), (c) thin membrane disease (TMD), (d) nephrotic-albuminuric IgA nephropathy (IgAN) (>3500 mg/24 hours), (e) macroalbuminuric IgAN (>300 mg/24 hours and <3500 mg/24 hours), and (f) microalbuminuric IgAN (<300 mg/24 hours) show the labeling at different intensities; the most intense staining was observed in the luminal aspect of the proximal tubules (PT), whereas staining of the distal tubules (DT) was at background levels. Bar = 50 μm.
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