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Fig. 1
Figure 1. Premature aging phenotype in high caloric intake (HCI) zebrafish: anatomical and behavioral changes, and increased mortality. (A) Images of 1-year old Control, 2-year old Control and 1-year old HCI fish with scoliosis. (B) Percent of fish with scoliosis within each condition; white bar—Control fish, 1–4 years of age, black bar—HCI fish, 1–2 years of age. (C) Bottom-dwelling, time spent swimming at the bottom third of the tank, following no treatment (solid bar) or after Diazepam administration (diagonal stripes), n = 6–8 fish per group, mean ± SEM, * p < 0.05 vs. 1-year old Control; # p < 0.05 Diazepam vs. no treatment. (D) Mortality rate in 1–4 year old Control and 1–2 year old HCI fish (see Section 4.1. for the size of each population).
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