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Fig. 1
Schematic diagram of results from a large-scale expression screening of human full-length cDNAs. (A) Synthetic mRNA for individual human full-length cDNA clone was injected to one to two-cell stage zebrafish embryos. Injected embryos were examined for morphological defects from early embryogenesis (6 hpf) to organogenesis (24–48 hpf). Total of sixty-four genes caused morphological defects. (B) Types of defects identified from the expression screening. Numbers in parentheses indicate the number of genes that caused particular defect. (C,D) Using bioinformatics tools including PROSITE, SMART and Motif Scan programs, identified genes are classified by biological processes they regulate.