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Fig. 7
Summary of the innate immune response to bacterial infection in larval zebrafish under different light conditions. The innate immune response can be divided into two states with enhanced bacterial clearance and survival when infection occurs under light exposure in the light/dark and constant light groups. This is, at least in part, the result of greater pro-inflammatory cytokine expression and neutrophil and macrophage recruitment to the infection site. In contrast, when infected during the dark condition (either under dark/light or constant darkness) there is reduced bacterial clearance and survival that coincides with a reduction in pro-inflammatory gene expression and leukocyte recruitment.