ZFIN Image: Pérez-López et al., 2017, Fig. 2

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Figure Caption

Fig. 2

a) Gold-triggered activation of prodrugs 4 a–c in A549 cancer cell culture. Negative controls: [Au]-resins (1 mg mL⁻¹); 4 a–c (10, 100, and 1 μm, respectively). Positive control: 5 a–c (10, 100, and 1 μm, respectively). Prodrug activation assay: [Au]-resins+4 a–c (10, 100, and 1 μm, respectively). Cell viability was measured at day 4 using PrestoBlue reagent. Error bars: ±SD from n=3. b) Bioorthogonal gold-mediated release of green fluorescent Rhodamine 110 from precursor 1 in the brain of a zebrafish. The presence of the [Au]-resin is indicated with a white arrow. Study of fluorescence intensity shows high statistical significance compared to the negative control (DMSO).

Acknowledgments

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