Fig. 1
Adult zebrafish are susceptible to Mycobacterium leprae infection. A, Hematoxylin-eosin (H-E)?stained section of a granuloma in the peritoneal cavity of a wild-type adult zebrafish 7 days after infection with 5 × 107 Thai53 strain M. leprae. Arrowheads indicate lymphocyte nuclei. B, Granuloma from a skin biopsy specimen from a patient with tuberculoid leprosy. The image is from the archives of the Lauro de Souza Lima Institute. C, Serial section of the granuloma in panel A, stained for acid-fast bacilli (AFB) to detect M. leprae; many bacteria are present (arrows). D, AFB-stained granuloma section from the peritoneal cavity of a similarly infected fish, 7 days after infection; few bacteria are present. Arrows indicate bacilli. Bars denote 10 ?m.