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Fig. S5
Zebrafish development experiments were used to examine the effect of the first-generation FLT3 inhibitors including CEP-701, MLN-518, sorafenib, and sunitinib on the Wnt/?-catenin signaling. CEP-701, MLN-518, sorafenib, or sunitinib was added to the fish water at 4hpf (more than 10 zebrafish embryos in each group). The representative images were taken after 24hpf. CEP-701 caused severe malformation and development delay. Scale bar, 200?m.
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