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Fig. S2
Effects of sex hormones on cell proliferation during liver tumor progression in adult krasV12 zebrafish. Wild type (wt) and krasV12 fish (4 months old) were treated with dox (doxycycline) alone, dox and E2, and dox and 11-KT, respectively, for a total of 7 days. Liver sections were stained for PCNA. (A-L) Representative images of PCNA staining of female and male wt and krasV12 liver after treatments of dox (A-D), dox and E2 treatment (E-H), or dox and 11-KT (I-L). Scale bar, 20 μm for all panels.
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