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Fig. 2
Live imaging of jaw joint cavitation.
(A–F) In double transgenic zebrafish, sox10:DsRed marks all chondrocytes and trps1:GFP labels nascent joint chondrocytes (arrow) and perichondrial cells at 3 and 7 dpf. By 14 dpf, a partial cavity (asterisk) was evident in 1/6 animals. In 3/3 animals at 1 mpf, 4/4 at 2 mpf, and 4/4 at 8 mpf, a fully formed cavity is evident and sox10:DsRed is expressed in a subset of trps1:GFP+ articular chondrocytes. Scale bar, 50 μm.
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