ZFIN Image: Sedykh et al., 2017, Fig. 6

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Fig. 6

Alx1 is a novel target of zic2 in the periocular neural crest. Embryos derived from zic2a^gbt133/+; zic2b^t104/zic2b^t104 parents were stained for alx1 expression by WISH. A: normal expression in periocular mesenchyme of sibling embryo. B: depleted expression in zic2 (arrow) in mutant embryo (39 out of 112 total, 2 expts). C-G: wild type embryos stained for alx1 expression by WISH. C-D: alx1 is expressed in frontonasal neural crest at 16 hpf. E, F: alx1 is expressed in periocular mesenchyme (*) at 24 hpf and 36 hpf. G: alx1 is expressed in the ethmoid plate (arrowhead) at 48 hpf. Embryos in A, B, C, and E are shown in lateral views, anterior to the left. Embryo in D is shown dorsally, anterior to the left. Embryos in F and G are shown in anterior views, ventral at the top.

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Reprinted from Developmental Biology, 429(1), Sedykh, I., Yoon, B., Roberson, L., Moskvin, O., Dewey, C.N., Grinblat, Y., Zebrafish zic2 controls formation of periocular neural crest and choroid fissure morphogenesis, 92-104, Copyright (2017) with permission from Elsevier. Full text @ Dev. Biol.