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Fig. 5
Co-exposures with 10 mM metronidazole (MTZ) in Tg(l-fabp:CFP-NTR)s891 and wild-type zebrafish embryos. Structures of all compounds tested are shown in (a). Embryos were exposed to MTZ at 48 hpf, and to 1% DMSO (1.5% DMSO-exposed animals were phenotypically indistinguishable) (b), retene (c), benzo[a]pyrene (B[a]P) (d), acetaminophen (APAP) (e), or flutamide (f) at 72 hpf. Additionally, wild-type embryos were exposed to flutamide (g). Imaging and evaluations were done for all animals at 120 hpf. Concentrations tested but not shown resulted in 100% mortality both in the presence and absence of MTZ.
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