ZFIN Image: Stainier et al., 2017, Fig. 8

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Figure Caption

Fig. 8

Poly I:C injection in medaka promotes CM proliferation in a macrophage-dependent manner following cardiac injury.

Adult zfmlc2 5.1 k:DsRED2-nuc medaka were injected with PBS or poly I:C immediately after injury, or with clodronate liposomes at 1 day before injury and poly I:C immediately after injury. Hearts were collected at 7 dpci, and CM proliferation was examined by EdU labeling and immunostaining for DsRED expression; dotted lines delineate the injured area. EdU positive CMs within 200 μm of the injured area were quantified and shown (B; n ≥ 3). Scale bars, 100 μm. The percentage of proliferating CMs was significantly higher in poly I:C-exposed hearts compared to both PBS- and CL + poly I:C-exposed hearts.

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