ZFIN Image: Lewis et al., 2017, Fig. S5

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Figure Caption

Fig. S5

Disc shedding is unaffected in osm-3/kif17^mw405 and cos2/kif7^mw406 retina. (Top, Left) TEM image of 7dpf wild-type retina. Depicted is an OS that has recently undergone disc shedding with a phagosome at the OS tip. Scale bar is 5 µm. (Top, Right) Inset of the white box of the left image clearly showing the phagosome as a distinct structure from the OS. Scale bar is 500 nm. (Bottom) Quantification of disc shedding in control, osm-3/kif17^mw405, and cos2/kif7^mw406 retina. Phagosomes were counted along an average total length of 235±2 µm of RPE for four biological replicates of each genotype. Neither the number of phagosomes per length of RPE nor the area of individual phagosomes show any significant differences between genotypes.

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Acknowledgments

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Reprinted from Developmental Biology, 425(2), Lewis, T.R., Kundinger, S.R., Pavlovich, A.L., Bostrom, J.R., Link, B.A., Besharse, J.C., Cos2/Kif7 and OSM-3/Kif17 Regulate Onset of Outer Segment Development in Zebrafish Photoreceptors Through Distinct Mechanisms, 176-190, Copyright (2017) with permission from Elsevier. Full text @ Dev. Biol.