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Fig. 2
Tcf7l1 depletion causes loss of dorso-anterior PMs. (A–B) Control and Tcf7l1 depleted Tg(α-actin:GFP) embryos at 72 hpf. Tcf7l1 depletion resulted in similar loss of dorso-anterior PMs as increasing Wnt signaling prior to gastrulation. EOMs (arrow), 1st and 2nd PMs are severely reduced and misorganized or lost (arrowhead). Ventral 1st and 2nd arch muscles are reduced (bracket). Views are anterior ventro-lateral. > 15 embryos were examined for each condition. Scale bar indicates 100 μm.
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Reprinted from Mechanisms of Development, 143, Mandal, A., Holowiecki, A., Song, Y.C., Waxman, J.S., Wnt signaling balances specification of the cardiac and pharyngeal muscle fields, 32-41, Copyright (2017) with permission from Elsevier. Full text @ Mech. Dev.