ZFIN Image: Mandal et al., 2017, Fig. S6

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Figure Caption

Fig. S6

Consequences of manipulation of early Wnt signaling on Fgf ligands. (A–I) Fgf3 expression in control, Tcf7l1 depleted, and Wnt8 depleted embryos at the designated stages. (J–R) Fgf8a expression in control, Tcf7l1 depleted, and Wnt8 depleted embryos at the designated stages. Changes in expression domains are consistent with effects of early Wnt signaling on anterior-posterior patterning. Arrows in A–C and J–L mark the anterior head and posterior limit of expression for the markers in the presumptive midbrain-hindbrain boundary. Arrows in G–I indicate expression in the pharyngeal endodermal pouches. Fgf3 expression in the pouches is not affected by manipulation of early Wnt signaling. Arrows in M-O indicate expression of fgf8a in the ALPM. Arrows in P-R indicated midbrain-hindbrain boundary expression of fgf8a. ≥ 10 embryos were analyzed for each condition. Scale bar indicates 100 μm.

Acknowledgments

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Reprinted from Mechanisms of Development, 143, Mandal, A., Holowiecki, A., Song, Y.C., Waxman, J.S., Wnt signaling balances specification of the cardiac and pharyngeal muscle fields, 32-41, Copyright (2017) with permission from Elsevier. Full text @ Mech. Dev.