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Fig. 9
Wnt signaling cell-autonomously inhibits PM specification. (A) Schematic of blastula cell transplantation method. (B, C) Representative donor cells that incorporated into the heart and PMs at 72 hpf. (D) Graph indicating the frequency of donor cell contribution in embryos to the heart and the PMs. WT donor cells → WT host transplants n = 240. Tcf7l depleted donor cells → WT host embryos n = 221. Tcf7l1 depleted donor cells contributed significantly more to the cardiomyocytes and less frequently to the PMs compared to WT donors. Images are lateral views with anterior leftwards. Scale bar indicates 100 μm.
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Reprinted from Mechanisms of Development, 143, Mandal, A., Holowiecki, A., Song, Y.C., Waxman, J.S., Wnt signaling balances specification of the cardiac and pharyngeal muscle fields, 32-41, Copyright (2017) with permission from Elsevier. Full text @ Mech. Dev.