|
Fig. S4
Decreased hair cell regeneration in JNK inhibition zebrafish can be partly rescued by BIO treatment. (A–D) BIO/SP600125-treated larvae had signifi cantly more GFP-positive hair cells in neuromasts when compared with SP600125-treated animals at 24 h after neomycin treatment. Scale bar = 10 μm. (E) Quantification of GFP-positive hair cells. *p < 0.05; **p < 0.001. (n = 38 neuromasts from control animals, n = 31 1 μM BIO-treated neuromasts, n = 34 10 μM SP600125-treated neuromasts, n = 31 SP600125/BIO-treated neuromasts. Con vs. SP600125: unpaired t test, two-tailed, t = 7.229, df = 70, p < 0.0001; Con vs. BIO: unpaired t test, two-tailed, t = 5.359, df = 67, p < 0.0001; SP600125 vs. BIO: unpaired t test, two-tailed, t = 10.99, df = 63, p < 0.0001; SP600125 vs. BIO+SP600125: unpaired t test, two-tailed, t = 2.456, df = 63, p = 0.0168; BIO+SP600125 vs. Con: unpaired t test, two-tailed, t = 4.545, df = 67, p < 0.0001).