ZFIN Image: Xiao et al., 2016, Fig. S14

Image

Figure Caption

Fig. S14

Dnmt3ab is required for myocardial proliferation. (a) Quantitative PCR showed that dnmt3ab was induced in injured hearts at 3, 7, and 14 dpa compared with sham hearts (**P <0.01; ***P <0.001; data presented are mean ± s.e.m.; paired Student’s t-test). (b) Quantitative PCR showed that nanoparticle-mediated dnmt3ab siRNA decreased the RNA level of dnmt3ab in wild-type hearts (*P <0.05; data presented are mean ± s.e.m.; unpaired Student’s t-test). (c-e) BrdU ⁺/Mef2C⁺ proliferating cardiomyocytes decreased in dnmt3ab siRNA hearts (d) compared with negative control (NC) siRNA heart (c) at 14 dpa. The number (n) of hearts analyzed in each group is indicated in each bar (***P <0.001; data presented are mean ± s.e.m.; paired Student’s t-test). Scale bar, 100μm.

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Nat. Commun.