ZFIN Image: Jiménez-Amilburu et al., 2016, Fig. S6

Image

Figure Caption

Fig. S6

DAPT-treated hearts form disorganized trabecular ridges

(A-D') 3D spinning disk images and surface renderings at mid-sagittal plane of 79 (A-B) and 98 (C-D) hpf Tg(myl7:MKATE-CAAX) zebrafish hearts. Dashed boxes show higher magnification images. DMSO-treated larvae show a smooth cardiac wall and clear trabecular ridges in the cardiac lumen at 79 (A and A', arrowheads) and 98 (C and C', arrowheads) hpf, while larvae treated with 100 μM DAPT starting at 48 hpf show a collapsed cardiac wall and disorganized trabecular structures at 79 (B and B', asterisks) and 98 (D and D', asterisks) hpf. V, ventricle; AVC, atrioventricular canal. Scale bars, 10 μm.

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