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Fig. 5
Phagocytosis of apoptotic bodies by microglia. (A-C) Double transgenic PC-ATTACTM/Tg(pU.1:gal4-uas:egfp) larvae with green fluorescent microglial cells in the zebrafish brain. PC ablation (16 h of 4OHT treatment) caused an increase in the numbers of microglial cells specifically in the cerebellum (B,D), accompanied by microglial activation based on ramified to ameboid morphology changes (E). (C) 4OHT treatment of Tg(pU.1:gal4-uas:egfp) control larvae had no effect on microglial cells. CCe, corpus cerebelli; TeO, tectum opticum. *P<0.05, ***P<0.001 (Student's t-test); n.s., not significant.
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