ZFIN Image: Modzelewska et al., 2016, Fig. S3

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Figure Caption

Fig. S3

MEK inhibitors prevent growth of tumors in an embryonic transplantation assay. Related to Figure 4. (A) Representative images of embryos at 24 hours post transplantation before treatment (3 dpf) and embryos that have been treated for five days (8 dpf) with DMSO control or 50 ?M MEK inhibitor U0126. (B) Quantification of immunofluorescence on the final day of treatment (8 dpf) shows a significant decrease in the transplanted tumor mass in U0126-treated embryos compared to control. (C) Analysis of embryo survival during treatment (3-8 dpf) with DMSO and U0126 shows that both treatments are well tolerated during this stage of development. Averages in (B-C) represent two independent experiments (+/-SEM).

Acknowledgments

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