ZFIN Image: Park et al., 2016, Fig. 1

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Figure Caption

Fig. 1

Loss of ewsa promotes tumorigenesis.

Total numbers of fish for each genotypes are: ewsa^w/w;tp53^w/w (n = 41), ewsa^w/m;tp53^w/w (n = 135), ewsa^m/m;tp53^w/w (n = 21), ewsa^w/w;tp53^w/m (n = 28), ewsa^w/m;tp53^w/m (n = 46), ewsa^m/m;tp53^w/m (n = 39), ewsa^w/w;tp53^m/m (n = 48), ewsa^w/m;tp53^m/m (n = 12), ewsa^m/m;tp53^m/m (n = 19). (A) Representative images of zebrafish. In images of ewsa and tp53mutants, tumors are indicated with an arrow (>). Scale bar: 1cm. (B) Tumor incidence is higher in ewsa^w/m;tp53^w/m and ewsa^m/m;tp53^w/m compared to ewsa^w/w;tp53^w/m; and in ewsa^w/m;tp53^m/m and ewsa^m/m;tp53^m/m compared to ewsa^w/w;tp53^m/m zebrafish. (C) Average age at tumor onset is lower in ewsa^w/m;tp53^w/m and ewsa^m/m;tp53^tp53w/m compared to ewsa^w/w;tp53^w/m; and in ewsa^w/m;tp53^m/m and ewsa^m/m;tp53^m/m compared to ewsa^w/w;tp53^m/m zebrafish. (D) Representative images of H&E staining of tumors observed in zebrafish. MPNST-like: malignant peripheral nerve sheath tumor-like; SRBCT: small round blue cell tumor.

Figure Data

Phenotype details

Acknowledgments

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