Fig. 10 S2
- ID
- ZDB-IMAGE-160817-15
- Publication
- Hatzold et al., 2016 - Tumor suppression in basal keratinocytes via dual non-cell-autonomous functions of a Na,K-ATPase beta subunit
- All Figures
- Figures for Hatzold et al., 2016
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Fig. 10 S2
mmp9 knockdown alleviates epidermal invasiveness.
Examples of whole mount immunofluorescence of laminin (red) and type II collagen (green) of the tail fin of 58 hpf psoriasis-/- embryos (a,b) and psoriasis-/- ; mmp9 MO embryos (c,d)-, counterstained with DAPI (blue). Actinotrichia disassembly (a′-d′) and basement membrane disruption (a′′-b′′) observed below epidermal aggregates (arrows in a′′′-d′′′) are strongly reduced upon knockdown of mmp9. In total (5 embryos examined per condition), 5/22 medium-sized fin fold aggregates were associated with BM fragmentation in mmp9 MO-injected mutants, compared to 19/19 in un-injected mutant controls.