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Fig. 2

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Fig. 2

Inhibition of Dnmts suggests that the regulation of DNA methylation is important for MG reprogramming. (A) Four-day postinjury 1016 tuba1a:gfp transgenic fish treated with 5-dAza show increased levels of endogenous (unstained) GFP. (B) 5-dAza inhibits the generation and localization of PCNA-positive MG-derived progenitors. *, mark the injury site in A and B. (C) Quantification of PCNA-positive nuclei per injury site. The value is normalized to the value of the 2-dpi control. *P < 0.02873. (D) Graphic depicting the localization of PCNA-positive nuclei within the retina at the indicated time points. 5-dAza perturbs the localization of PCNA-positive nuclei at 4 and 7 dpi. In C and D error bar extending from the box represent standard deviation. *P < 0.04128. GCL, ganglion cell layer; INL, inner nuclear layer; IPL, inner plexiform layer; ONL, outer nuclear layer; OPL, outer plexiform layer. (Scale bars, 50 µm.)

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This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Proc. Natl. Acad. Sci. USA