ZFIN Image: Lahvic et al., 2013, Fig. 3

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Figure Caption

Fig. 3

Heart jog direction was randomized by hspb12 knockdown (A) Two morpholinos that target hspb12 significantly increased right and midline heart jogs at the expense of leftward jogs compared to control MO (Χ² test; p<0.001 for hspb12MO1 and p<0.05 for hspb12MO2). (B) Yolk injections of hspb12MO1 increased midline hearts but not rightward jogs. Combinations of both hspb12 MOs were lethal. (C) Combined hspb7MO1 and hspb12MO1 (0.25 pmol individually or in combination) injected at the 1-cell stage increased midline hearts and rightward jogs significantly compared to control (Χ² test; all p<0.001). Combined hspb7MO1+hspb12MO1 (0.25 pmol each) gave significantly more abnormal jogs than 0.25 pmol hspb7MO1 alone (Χ² test; p<0.05).

Figure Data

Phenotype details

Acknowledgments

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Reprinted from Developmental Biology, 384(2), Lahvic, J.L., Ji, Y., Marin, P., Zuflacht, J.P., Springel, M.W., Wosen, J.E., Davis, L., Hutson, L.D., Amack, J.D., and Marvin, M.J., Small heat shock proteins are necessary for heart migration and laterality determination in zebrafish, 166-180, Copyright (2013) with permission from Elsevier. Full text @ Dev. Biol.