IMAGE

Fig. 1

ID

ZDB-IMAGE-160701-57

Antibodies

Publication

Valvezan et al., 2014 - Oncogenic mutations in Adenomatous Polyposis Coli (Apc) activate mechanistic Target of Rapamycin Complex 1 (mTORC1)

All Figures

Figures for Valvezan et al., 2014

Image

Figure Caption

Fig. 1

Activation of mTORC1 in apc^mcr/mcr zebrafish. Western blot analysis using antibodies to phosphorylated S6 (p-S6), indicating mTORC1 activity, or total S6 on whole embryo lysates from pooled wild-type and heterozygous apc^mcr/+ zebrafish or homozygous apc^mcr/mcr zebrafish at 3 or 4 dpf. mTORC1 activity was increased in the homozygous apc^mcr/mcr zebrafish. (B) Immunohistochemical staining of sagittal sections from wild-type or homozygous apc^mcr/mcr zebrafish at 3 dpf using antibodies to phosphorylated or total S6 and counterstaining with DAPI. mTORC1 was aberrantly active in multiple mesodermal and endodermal derivatives in the homozygous apc^mcr/mcr zebrafish.

Figure Data

Expression / Labeling details

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Dis. Model. Mech.