ZFIN Image: Chen et al., 2016, Fig. 6

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Figure Caption

Fig. 6

Roles of Cyp2aa9 in HSC development act at the step of PGH2-to-PGE2 conversion.

(a-f) Down-regulation of cmyb expression caused by Indomethacin (Indo) could not be rescued by cyp2aa9 mRNA, and could not be exacerbated by cyp2aa9MO. (g-n) The PGE2 precursors AA, PGG2 or PGH2 could not rescue the defective HSC formation in cyp2aa9 morphants. (o) Illustration of the prostaglandin synthesis and PGE2/cAMP/PKA pathway involved in HSC development in zebrafish. Note that Cyp2aa9 acts at the step of PGH2-to-PGE2 conversion. Indo, non-selective cyclooxygenases inhibitor. Forskolin, cAMP activator. H89, PKA inhibitor. All the views of embryos are lateral, anterior left, dorsal top.

Acknowledgments

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