ZFIN Image: Berg et al., 2016, Fig. 3

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Figure Caption

Fig. 3

snapc1b Mutant Macrophages Fail to Participate in Granuloma Formation

(A) Confocal images of granulomas in the hindbrain ventricle of snapc1b mutant larvae and WT siblings with green fluorescent macrophages at 2 dpi with 100 red fluorescent Mm. Scale bar, 60 µm.

(B) Tracks of macrophage movement following granuloma formation in snapc1b mutant larvae and WT siblings shown in (A). Tracks are coded for speed. Tracks created by vacuolated macrophages are indicated with an asterisk.

(C and D) Speed (C) and displacement (D) of snapc1b mutant and WT sibling macrophages in (A and B). Statistical significance was assessed using one-way ANOVA with Sidak’s post-test.

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Acknowledgments

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Reprinted from Cell, 165, Berg, R.D., Levitte, S., O'Sullivan, M.P., O'Leary, S.M., Cambier, C.J., Cameron, J., Takaki, K.K., Moens, C.B., Tobin, D.M., Keane, J., Ramakrishnan, L., Lysosomal Disorders Drive Susceptibility to Tuberculosis by Compromising Macrophage Migration, 139-152, Copyright (2016) with permission from Elsevier. Full text @ Cell