ZFIN Image: Cofer et al., 2016, Fig. 6

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Figure Caption

Fig. 6

Activation of the HH pathway upregulates PDGF. Larvae were incubated in 30µM purmorphamine, a HH receptor agonist, at 2dpf. (A) PED-6 gallbladder uptake shows decreased gallbladder staining in incubated larvae (p≤.00001) (B) PDGF-AA protein expression of purmorphamine-incubated larvae relative to the control (ctrl) at 5dpf. (B′) PDGF-AA protein quantification of two independent experiments with standard deviations. (C,D) Confocal projections of cytokeratin-18 immunostaining of livers from 5dpf control (ctrl) and purmorphamine (pur) incubated larvae. Numbers refer to individuals exhibiting comparable morphology as representative image.

Acknowledgments

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