ZFIN Image: Salhi et al., 2015, Fig. 5

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Figure Caption

Fig. 5

Constitutive activation of protein S6 kinase, 90 kDa, polypeptide 1 (RSK1) accelerates melanoma tumor onset and invasion in zebrafish. A: Melanoma-free survival curve of miniCoopR-green fluorescent protein (GFP)-, miniCoopR-Myr-RSK1-, and miniCoopR-RSK-deltaCCT-injected zebrafish. B: Histologic sections of zebrafish RSK1dCCT- and Myr-RSK1-expressing melanomas were stained with hematoxylin and eosin to assess tumor invasion depth. Arrows indicate muscular invasion by melanoma cells. C: Depth of invasion was measured for each tumor and was quantified by averaging the depth of invasion of four tumors for each group (RSK1dCCT and Myr-RSK1). Data are given as means � SEM. ***P < 0.001 compared with dominant-negative RSK1-expressing tumors.

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