Fig. 3
The effects of Ran deficiency on the expression of early eye differentiation markers. (A-D) Typical expression patterns of rx1 mRNA on the eyes of WT and Ran-deficient embryos. While sizes are different, note that the patterns of pax6 were not significantly changed. (E-H) Typical expression patterns of pax6 mRNA on the eyes of WT and ran-deficient embryos. dd: dorsal diencephalon. (I,J) The expression patterns of pax2 mRNA on the eyes of WT and ran-deficient embryos. (K,L) The expression patterns of fgf8 mRNA on the eyes of WT and Ran-deficient embryos. (A, B, E, F, I - L) Lateral view with anterior to the left; (C,D,G,H) dorsal view with anterior to the top. MHB, midbrain/hindbrain boundary; OS, optic stalk. All images are representative of at least three repeats with n>25 for each repeat.