Fig. S11
Decreased Fhl1b activity inhibits liver and exocrine pancreas differentiation.
(A and B) Confocal images of Tg(ptf1a:GFP)jh1 control embryos (A) and fhl1b morphants (B), stained for Prox1 (blue) and Islet (red). The expression domain of the Prox1 and Tg(ptf1a:GFP)jh1 was reduced in fhl1b morphants (B) compared to that of control embryos (A). (C and D) Confocal images of Tg(fabp10a:RFP, ela3l:EGFP)gz12 control embryos (C) and fhl1b MO-injected larvae (D) at 96 hpf. The expression domain of the Tg(fabp10a:RFP, ela3l:EGFP)gz12 was reduced both in the liver and exocrine pancreas in fhl1b MO-injected larvae (D) compared to that of control larvae (C). A-D, confocal projection images, ventral views, anterior to the top. Scale bars, 20 µm.