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Fig. S4

ID: ZDB-IMAGE-160314-9
Publication: Tulotta et al., 2016 - Inhibition of signaling between human CXCR4 and zebrafish ligands by the small molecule IT1t impairs the formation of triple-negative breast cancer early metastases in a zebrafish xenograft model
All Figures: Figures for Tulotta et al., 2016

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Figure Caption

Fig. S4

Micrometastasis formation occurs in cxcl12 single ligand mutants. Engraftment of MDA-MB-231-B cell line resulted in micrometastasis formation in the tail fin region, characterized by invading single cells in both the cxcl12b ^-/- mutant and wt siblings at 2 and 4 dpi (A) and tumor burden in wt, cxcl12a ^-/- and cxcl12b ^-/- larvae at 2 dpi (B and C). The trend was not statistically significant (One-way ANOVA and Bonferroni post hoc test). Number of larvae in (A): n=30 (wt 2 dpi), n=20 (cxcl12b ^-/- 2 dpi), n=19 (wt 4 dpi) and n=15 (cxcl12b ^-/- 4 dpi). Number of larvae in (B): n= 23 (wt), n=27 (cxcl12a ^-/-) and n=27 (cxcl12b ^-/-). Scale bars: 50 µm.

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