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Fig. 1
Vivo conjugated Morpholino oligomer (MO) caused developmental delays and uncharacterized aggregates in zebrafish embryos.
When treated with 20 µM dnd-MO, embryos developed normally and reached (A) 1K cell stage after a 3 hour immersion and (B) 30-50% epiboly stage after a 5 hour immersion. When treated with 20 µM Vivo conjugated dnd-MO (dnd-MO-Vivo), embryo development was slightly delayed and only reached (C) 256-512 cell stage with aggregates found between the chorion and blastodisc (arrows) after a 3 hour immersion, and only reached (D) sphere stage with more aggregates (arrows) after a 5 hour immersion. Scale bar = 200 µm.
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