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Fig. 9
Partial rescue of clo-/- ocular phenotype by blocking cell death. A–C: Eye histology of wild-type (A) and clo-/- (B) embryos at 72 hpf, and of clo-/- embryos injected with a morpholino targeting p53 (p53 MO; C). D–F: Cell death, visualized by TUNEL staining in sections from 72 hpf embryos (E,F) is significantly reduced in p53 morphant clo-/- as compared to uninjected clo-/- (*** in D; P < 0.001). Two outliers from the MO group are not included in the graph as they showed very high levels of cell death, suggesting an unsuccessful MO injection. LE, lens. Scale bar = 50 µm in B (applies to all images).
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