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Fig. 10
Retinal phenotypes in clo-/-; p53 morphants. A–C: Anti-SV2 (synaptic vesicle 2) staining in wild type (A), clo-/- (B), and clo-/- p53 morphants (C). The organization of the IPL (inner plexiform layer) appears partially rescued in the morphant, but the thickness of this layer and the presence of the OPL (outer plexiform layer) are not rescued. D–F: ZPR1 (cone photoreceptor) staining in wild type (D), clo-/- (E), and clo-/- p53 morphants (F). Arrows in F show ectopic ZPR1+ profiles. G,G′: The extent of ZPR1 labeling (G) is not significantly rescued in clo-/- p53 morphants (P = 0.11), but the distribution of ZPR1+ cells (G′) is significantly different in clo-/- morphant retinas as compared to clo-/- (P < 0.03). H–J: ZRF1 (M&uumL;ller glia) staining in wild type (H), clo-/- (I), and clo-/-p53 morphants (J), showing no rescue of the presence or morphology of Mqller glia (* asterisks denotes normal location of endfeet). LE, lens. Scale bar = 50 µm in B (applies to all images).