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Fig. 5
Blocking TRβ receptor accelerates OT reinnervation. A. Brown staining represents biocytin labeled RGC axons. B. Quantification of the area covered by RGC axons in the OT of UC and C1 fish. Data represent mean ± SEM (n = 6 animals/group). ***p < 0.0001 by unpaired t-test. C. Immunofluorescent detection of Gap43 protein (red) in RGC axons (arrow) arriving in the OT. Cell nuclei are stained with DAPI (blue). Pictures are representative images for n = 4 animals/group. Scale bar - 20 µm. For all panels: UC-untreated control, C1-compound 1 treated, S-sham operated, X-optic nerve crushed, OT-optic tectum.
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Reprinted from Molecular and cellular neurosciences, 68, Bhumika, S., Lemmens, K., Vancamp, P., Moons, L., Darras, V.M., Decreased thyroid hormone signaling accelerates the reinnervation of the optic tectum following optic nerve crush in adult zebrafish, 92-102, Copyright (2015) with permission from Elsevier. Full text @ Mol. Cell Neurosci.