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Fig. S4
Cyp26a1 is required for the non-cell autonomous loss of RA signaling in vp-rar expressing embryos. (A?A2, B?B2) Tg(β-actin:GDBD-RLBD);(UAS:EGFP) donor cells transplanted into WT hosts or Cyp26a1 deficient hosts injected with vp-rar mRNA have bright EGFP expression in the trunk.
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Reprinted from Developmental Biology, 405(1), Rydeen, A., Voisin, N., D'Aniello, E., Ravisankar, P., Devignes, C.S., Waxman, J.S., Excessive feedback of Cyp26a1 promotes cell non-autonomous loss of retinoic acid signaling, 47-55, Copyright (2015) with permission from Elsevier. Full text @ Dev. Biol.