ZFIN Image: Yang et al., 2015, Fig. S9

Image

Figure Caption

Fig. S9

plk2b regulates intersomitic vessel angiogenic sprouting during zebrafish vascular development. (A–D) Time-lapse imaging of EC migration during intersomitic vessel (ISV) elongation in Tg(fli1a:eGFP) fish from 22–32 hpf shows that ISVs of (B) plk2b MO1 injected and (C) dn-plk2b RNA injected fish failed to sprout and elongate to form the DLAV (open arrowheads), whereas (D) 160 pg plk2b RNA injected fish appeared to not only develop the DLAV earlier (yellow arrowheads), but also grow additional ISV branches that connect throughout the somites (white arrowheads). Top, dorsal longitudinal anastomotic vessel; bottom, dorsal aorta/cardinal vein. Scale bar, 80 µm.

Acknowledgments

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Reprinted from Developmental Biology, 404(2), Yang, H., Fang, L., Zhan, R., Hegarty, J.M., Ren, J., Hsiai, T.K., Gleeson, J.G., Miller, Y.I., Trejo, J., Chi, N.C., Polo-like kinase 2 regulates angiogenic sprouting and blood vessel development, 49-60, Copyright (2015) with permission from Elsevier. Full text @ Dev. Biol.