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Fig. S1 Knockdown of mecp2 enhances Notch signaling activity in the developing brain. RNA in situ hybridization with notch1a, notch1b, deltaA, deltaB, deltaC, her4.1, and her2 probes in controls (A-J) and mecp2 morphants (A′-J′) at 48 hpf. Note up-regulated expression of these Notch signaling genes in the developing brain of mecp2 morphants. Lateral views (A-A′; C-C′; E-E′; G-G′; I-I′; K-K′; M-M′) and dorsal views (B-B′; D-D′; F-F′; H-H′; J-J′; L-L′; N-N′) with the anterior to the left. The numbers in the bottom right corner represent phenotypic embryos/total embryos.
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Full text @ J. Cell Sci.