ZFIN Image: Yang et al., 2015, Fig. 4

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Figure Caption

Fig. 4

Axon wrapping by oligodendrocyte membrane is abnormal in dync1h1^vu76 mutant larvae. Panels show images captured from time-lapse movies of oligodendrocytes marked by Tg(nkx2.2:EGFP-CaaX) reporter expression beginning at 2.5 dpf. Time elapsed since beginning of movies is marked on the left. Images were obtained from lateral view of the trunk spinal cord, with dorsal up. A: In wild-type larvae, oligodendrocyte membrane processes contact axons, initiate tight wrapping and lengthen bi-directionally to form myelin sheaths (see example sheaths 1 and 2). Once formed, most sheaths are stable and rarely lost. B: In dync1h1^vu76 mutant larvae, some sheaths do not lengthen (e.g., sheath 3) and some shorten and are subsequently lost (e.g., sheath 4). Sheath 5 forms a relatively long segment.

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Acknowledgments

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